Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GUSB | P08236 | 9/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | DHODH | Q02127 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12171732 | 0.84 | NPC1 (0.66) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11615095 | 0.84 | ALDH1A1 (0.58) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12171886 | 0.84 | PPARD (0.56) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL23084666 | 0.81 | GUSB (0.47) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL6450847 | 0.80 | RAB9A (0.64) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12171992 | 0.80 | NPC1 (0.53) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL20587546 | 0.79 | GUSB (0.55) | NPC1RAB9AALDH1A1GUSB | |
| SCHEMBL31513296 | 0.79 | GUSB (0.55) | NPC1RAB9AALDH1A1GUSB | |
| SCHEMBL29771147 | 0.79 | GUSB (0.55) | NPC1RAB9AALDH1A1GUSB | |
| SCHEMBL11611975 | 0.77 | KDM4E (0.68) | NPC1RAB9AALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | TREVENA, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234946-A1 | COMPOUNDS FOR MODULATING S1P1 ACTIVITY AND METHODS OF USING THE SAME | S1PR1, S1PR2, S1PR3 | NPC1 301/4885RAB9A 3056/4885ALDH1A1 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.