Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21022113 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1PDE3BPDE3ARPS6KA3 | |
| SCHEMBL22820004 | 0.79 | ABL1 (0.50) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL16574098 | 0.78 | MAP4K4 (0.48) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL3641688 | 0.77 | TNKS (0.53) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL14850869 | 0.77 | ACHE (0.50) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL25840018 | 0.76 | PTGS2 (0.51) | PTGS2PTGS1AKR1C3AKR1C2 | |
| SCHEMBL17971121 | 0.75 | PTGS2 (0.44) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL17971123 | 0.75 | PTGS2 (0.44) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL13703910 | 0.74 | AKR1C3 (0.49) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL394650 | 0.72 | ALOX5AP (0.48) | PTGS2PTGS1DAPK3NTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134698-A1 | PYRIDAZINE-1(6H)-6-OXO COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 深圳信立泰药业股份有限公司 | 2023-07-20 | — | — | WO | disclosed |