Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 4/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.44 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL654212 | 0.96 | — | — | |
| Glycine SCHEMBL6237182 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL6237271 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL16601 | 0.92 | CA4 (0.50) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL583139 | 0.92 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL2916896 | 0.92 | CA4 (0.50) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5712834 | 0.88 | CA4 (0.47) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL22948 | 0.88 | — | — | |
| Glycine SCHEMBL7632674 | 0.88 | CA4 (0.47) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL1633657 | 0.88 | CA4 (0.47) | CA4GLRA1SLC6A9OR51E2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110268235-A1 | BORON-10 ENHANCED THERMAL ENERGY | GURIN MICHAEL | 2011-11-03 | — | — | US | claimed |
| WO-2005011737-A2 | PHARMACEUTICAL COMBINATIONS AND FORMULATIONS WITH IMPROVED STABILITY | CIPLA LIMITED (IN) | 2005-02-10 | — | — | WO | claimed |
| EP-1006997-B1 | EFFERVESCENT MICROSPHERES AND METHOD FOR MAKING THEM | PF MEDICAMENT (FR) | 2003-07-02 | — | — | EP | claimed |
| US-6210711-B1 | MULTILAYER MICROSPHERES CONTAINING AN ACID SUBSTANCE, A BASIC SUBSTANCE, AND A WATER-SOLUBLE ISOLATING AGENT WHICH, WHEN IT DISSOLVES IN WATER, AFTER ALMOST INSTANT EFFERVESCENCE, BRINGS ABOUT A HOMOGENEOUS DISPERSION OF ACTIVE PRINCIPAL(S) | PIERRE FABRE MEDICAMENT (FR) | 2001-04-03 | — | — | US | claimed |
| US-9951949-B1 | Ultra-high energy density and emissivity for energy conversion | GURIN MICHAEL H (US) | 2018-04-24 | — | — | US | disclosed |
| US-20110268235-A1 | BORON-10 ENHANCED THERMAL ENERGY | GURIN MICHAEL | 2011-11-03 | — | — | US | disclosed |
| US-20070218131-A1 | EFFERVESCENT FORMULATIONS COMPRISING DESMOPRESSIN | ARDANA BIOSCIENCE LIMITED (GB) | 2007-09-20 | — | — | US | disclosed |
| CN-1953738-A | Effervescent agent containing desmopressin | ARDANA BIOSCIENCE LTD (GB) | 2007-04-25 | — | — | CN | disclosed |
| US-20070087054-A1 | EFFERVESCENT FORMULATIONS OF OXYTOCIN | ARDANA BIOSCIENCE LIMITED (GB) | 2007-04-19 | — | — | US | disclosed |
| US-20070071818-A1 | EFFERVESCENT FORMULATIONS COMPRISING APOMORPHINE | ARDANA BIOSCIENCE LIMITED (GB) | 2007-03-29 | — | — | US | disclosed |
| EP-1725220-A1 | EFFERVESCENT FORMULATIONS COMPRISING DESMOPRESSIN | Ardana Bioscience Limited (GB) | 2006-11-29 | — | — | EP | disclosed |
| US-20060141032-A1 | Effervescent formulations comprising apomorphine | ARDANA BIOSCIENCE LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| US-20060034920-A1 | Effervescent formulations of oxytocin | ARDANA BIOSCIENCE LIMITED (GB) | 2006-02-16 | — | — | US | disclosed |
| WO-2005089724-A1 | EFFERVESCENT FORMULATIONS COMPRISING DESMOPRESSIN | ARDANA BIOSCIENCE LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |
| EP-1556048-A1 | EFFERVESCENT FORMULATIONS COMPRISING APOMORPHINE | Ardana Bioscience Limited (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1549289-A1 | EFFERVESCENT FORMULATIONS OF OXYTOCIN | Ardana Bioscience Limited (GB) | 2005-07-06 | — | — | EP | disclosed |
| WO-2005011737-A2 | PHARMACEUTICAL COMBINATIONS AND FORMULATIONS WITH IMPROVED STABILITY | CIPLA LIMITED (IN) | 2005-02-10 | — | — | WO | disclosed |
| WO-2004026309-A1 | EFFERVESCENT FORMULATIONS COMPRISING APOMORPHINE | ARDANA BIOSCIENCE LIMITED (GB) | 2004-04-01 | — | — | WO | disclosed |
| WO-2004026279-A1 | EFFERVESCENT FORMULATIONS OF OXYTOCIN | ARDANA BIOSCIENCE LIMITED (GB) | 2004-04-01 | — | — | WO | disclosed |
| US-6210711-B1 | MULTILAYER MICROSPHERES CONTAINING AN ACID SUBSTANCE, A BASIC SUBSTANCE, AND A WATER-SOLUBLE ISOLATING AGENT WHICH, WHEN IT DISSOLVES IN WATER, AFTER ALMOST INSTANT EFFERVESCENCE, BRINGS ABOUT A HOMOGENEOUS DISPERSION OF ACTIVE PRINCIPAL(S) | PIERRE FABRE MEDICAMENT (FR) | 2001-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070218131-A1 | EFFERVESCENT FORMULATIONS COMPRISING DESMOPRESSIN | AVPR2, AVPR1A, AVPR1B | CA4 3958/4885GLRA1 1689/4885SLC6A9 924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.