Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2584773 | 0.77 | HPGD (0.51) | HPGDLMNAALDH1A1L3MBTL1 | |
| SCHEMBL8435113 | 0.77 | HPGD (0.50) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL13302265 | 0.77 | HPGD (0.69) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL30260147 | 0.77 | HPGD (0.69) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL5524312 | 0.76 | CA1 (0.72) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL5523403 | 0.76 | CA1 (0.80) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL4259746 | 0.75 | LMNA (0.50) | HPGDMAPTLMNAPOLBALDH1A1 | |
| SCHEMBL20424296 | 0.74 | MEN1 (0.35) | HPGDPDE4BKMT2AMAPTLMNA | |
| SCHEMBL5527334 | 0.74 | HPGD (0.46) | HPGDCA1CA2CA7CA9 | |
| SCHEMBL3052857 | 0.73 | PDE4B (0.69) | CA1CA2CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |