SCHEMBL5527334

SCHEMBL5527334

COc1ccc(C(=O)N2CCc3onc(OC(=O)O)c3C2)cc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.46
DRD4 P21917 1/20 0.45
LMNA P02545 2/20 0.44
GAA P10253 1/20 0.44
KCNK3 O14649 1/20 0.43
NPC1 O15118 1/20 0.43
POLB P06746 2/20 0.42
MAPT P10636 2/20 0.41
ALDH1A1 P00352 2/20 0.41
TSHR P16473 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
CA14 Q9ULX7 1/20 0.41
PTGDR2 Q9Y5Y4 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4D Q08499 1/20 0.41
CHRM3 P20309 1/20 0.41
MTHFD2 P13995 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4259746 0.84 LMNA (0.50) HPGDDRD4LMNAGAAKCNK3
SCHEMBL5538970 0.82 HSP90AA1 (0.41) NPC1MAPTALDH1A1TSHRMTHFD2
SCHEMBL5528804 0.81 HPGD (0.40) HPGDNPC1MAPTALDH1A1TSHR
SCHEMBL5539180 0.81 HPGD (0.52) HPGDNPC1MTHFD2L3MBTL1
SCHEMBL5529341 0.79 PKM (0.47) LMNANPC1ALDH1A1TSHRL3MBTL1
SCHEMBL5532995 0.77 HSD11B1 (0.45) KCNK3
SCHEMBL15300410 0.77 ALDH1A1 (0.47) LMNANPC1POLBMAPTALDH1A1
SCHEMBL15300348 0.77 HPGD (0.48) HPGDLMNANPC1MAPTALDH1A1
SCHEMBL15062704 0.76 LMNA (0.50) HPGDLMNAGAANPC1ALDH1A1
SCHEMBL5526654 0.75 ALDH1A1 (0.35) HPGDDRD4NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP claimed
EP-1869053-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2007-12-26 EP claimed
WO-2006105945-A1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS Grünenthal GmbH (DE) 2006-10-12 WO claimed
EP-1869053-B1 SUBSTITUTED 4,5,6,7-TETRAHYDRO-ISOXAZOLO[4,5-C]PYRIDINE COMPOUNDS AND THEIR USE IN THE PRODUCTION OF MEDICAMENTS GRUENENTHAL GMBH (DE) 2013-10-09 EP disclosed