Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.71 |
| ▸ | BCHE | P06276 | 4/20 | 0.71 |
| ▸ | ACHE | P22303 | 4/20 | 0.71 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.62 |
| ▸ | TCF7L2 | Q9NQB0 | 4/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | MERTK | Q12866 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | UBE2N | P61088 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2580376 | 0.85 | RAD52 (0.76) | APPBCHEACHECCNE2CCNE1 | |
| SCHEMBL25867340 | 0.84 | APP (0.64) | APPBCHEACHECTNNB1TCF7L2 | |
| SCHEMBL25867456 | 0.83 | APP (0.62) | APPBCHEACHECTNNB1TCF7L2 | |
| SCHEMBL25309780 | 0.83 | APP (0.67) | APPBCHEACHECTNNB1TCF7L2 | |
| SCHEMBL25867222 | 0.82 | APP (0.70) | APPBCHEACHECTNNB1TCF7L2 | |
| SCHEMBL25867149 | 0.82 | APP (0.66) | APPBCHEACHECTNNB1TCF7L2 | |
| SCHEMBL4866829 | 0.81 | PDE5A (0.78) | APPBCHEACHECCNE2CCNE1 | |
| SCHEMBL14266699 | 0.79 | APP (0.59) | APPBCHEACHENPY5RRAD52 | |
| SCHEMBL14256550 | 0.79 | APP (0.61) | APPBCHEACHENPY5RRAD52 | |
| SCHEMBL30896249 | 0.78 | APP (0.60) | APPBCHEACHENPY5RRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133221-A2 | SMARCA2/4 INHIBITION AS A STRATEGY TO TREAT TUMORS THAT HARBOR ABERRANT BAF ASSEMBLIES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-13 | — | — | WO | disclosed |