Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.68 |
| ▸ | PDE5A | O76074 | 4/20 | 0.68 |
| ▸ | USP1 | O94782 | 2/20 | 0.54 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13929497 | 0.91 | APP (0.70) | APPPDE5AUSP1WDR48MAPT | |
| SCHEMBL25306105 | 0.88 | APP (0.74) | APPPDE5AUSP1WDR48MAPT | |
| SCHEMBL3782735 | 0.84 | APP (0.81) | APPPDE5AUSP1WDR48MAPT | |
| SCHEMBL3113122 | 0.82 | APP (1.00) | APPPDE5AMAPTKMT2ALMNA | |
| SCHEMBL29388255 | 0.82 | APP (1.00) | APPPDE5AMAPTKMT2ALMNA | |
| SCHEMBL3106597 | 0.81 | APP (0.85) | APPPDE5AUSP1WDR48MAPT | |
| SCHEMBL25867456 | 0.79 | APP (0.62) | APPPDE5AMAPTKMT2ALMNA | |
| SCHEMBL3113251 | 0.79 | APP (0.81) | APPPDE5AMAPTKMT2ALMNA | |
| SCHEMBL3121152 | 0.79 | APP (0.81) | APPPDE5AMAPTKMT2ALMNA | |
| SCHEMBL3638414 | 0.78 | APP (0.74) | APPPDE5AUSP1WDR48MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023133221-A2 | SMARCA2/4 INHIBITION AS A STRATEGY TO TREAT TUMORS THAT HARBOR ABERRANT BAF ASSEMBLIES | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2023-07-13 | — | — | WO | disclosed |