Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25870573 | 0.84 | PTPN1 (0.45) | POLBNPSR1L3MBTL1PTPN1EPHX2 | |
| SCHEMBL12086276 | 0.79 | POLB (0.54) | POLBNPSR1L3MBTL1PTPN1EPHX2 | |
| SCHEMBL25876578 | 0.78 | ITGB3 (0.39) | EPHX2ITGB3ITGA2B | |
| SCHEMBL19359830 | 0.77 | PTPN1 (0.44) | POLBNPSR1L3MBTL1PTPN1EPHX2 | |
| SCHEMBL22151607 | 0.76 | POLB (0.51) | POLBNPSR1L3MBTL1PTPN1EPHX2 | |
| SCHEMBL864304 | 0.76 | POLB (0.50) | POLBNPSR1L3MBTL1PTPN1EPHX2 | |
| SCHEMBL10274873 | 0.76 | KEAP1 (0.48) | KMT2A | |
| SCHEMBL12252175 | 0.75 | — | — | |
| SCHEMBL19022019 | 0.75 | EPHX1 (0.42) | POLBEPHX2KMT2ARAB9A | |
| SCHEMBL3317282 | 0.74 | POLB (0.49) | POLBNPSR1L3MBTL1PTPN1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116920-A1 | PENTA- FUSED HEXA-HETEROCYCLIC COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 杭州多域生物技术有限公司 | 2023-06-29 | — | — | WO | disclosed |