SCHEMBL25872106

SCHEMBL25872106

NC(=O)c1ccc(S(=O)(=O)NNC(=O)c2ccc(O)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.71
MEN1 O00255 1/20 0.71
KAT6A Q92794 3/20 0.62
GFER P55789 1/20 0.59
GAA P10253 11/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
KDM4E B2RXH2 1/20 0.52
HTT P42858 1/20 0.51
ALDH1A1 P00352 1/20 0.51
HPGD P15428 1/20 0.51
POLB P06746 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25872128 0.89 KAT6A (0.60) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25872095 0.88 KMT2A (0.68) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25241197 0.87 KMT2A (0.71) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25870909 0.84 GAA (0.78) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25872681 0.84 KMT2A (0.71) KMT2AMEN1KAT6AGFERGAA
SCHEMBL28979677 0.84 GAA (0.76) KMT2AMEN1KAT6AGFERGAA
SCHEMBL26104327 0.83 MEN1 (1.00) KMT2AMEN1KAT6AGAAHTT
SCHEMBL25872786 0.83 KMT2A (0.69) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25288758 0.81 KMT2A (0.62) KMT2AMEN1KAT6AGFERGAA
SCHEMBL25872083 0.80 GFER (0.91) KMT2AMEN1KAT6AGFERGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN claimed
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND AUTOTAC INC. (KR) 2023-06-08 US disclosed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND UBR4, UBQLN2, UBTF KMT2A 1391/4885MEN1 3583/4885KAT6A 1150/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.