SCHEMBL25872128

SCHEMBL25872128

NC(=O)c1ccc(C(=O)NNS(=O)(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 4/20 0.60
GFER P55789 1/20 0.57
KMT2A Q03164 3/20 0.56
MEN1 O00255 2/20 0.56
GAA P10253 9/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
LMNA P02545 2/20 0.53
KDM4E B2RXH2 1/20 0.51
HTT P42858 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
TDP1 Q9NUW8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25872106 0.89 KMT2A (0.71) KAT6AGFERKMT2AMEN1GAA
SCHEMBL25241197 0.89 KMT2A (0.71) KAT6AGFERKMT2AMEN1GAA
SCHEMBL6396355 0.86 KAT6A (0.78) KAT6AKMT2AMEN1GAALMNA
SCHEMBL25284025 0.84 KAT6A (0.65) KAT6AGFERKMT2AMEN1GAA
SCHEMBL5672239 0.82 GFER (0.86) KAT6AGFERKMT2AGAAL3MBTL1
SCHEMBL28979677 0.82 GAA (0.76) KAT6AGFERKMT2AMEN1GAA
SCHEMBL25872095 0.77 KMT2A (0.68) KAT6AGFERKMT2AMEN1GAA
SCHEMBL4818961 0.76 MEN1 (0.83) KMT2AMEN1L3MBTL1LMNASMN1; SMN2
SCHEMBL20567504 0.76 LMNA (0.62) KAT6AKMT2AMEN1GAAL3MBTL1
SCHEMBL27581323 0.76 HTR6 (0.67) KMT2AMEN1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4144722-A1 COMPOUND AS UBR BOX DOMAIN LIGAND Autotac Inc. (KR) 2023-03-08 EP claimed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN claimed
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND AUTOTAC INC. (KR) 2023-06-08 US disclosed
EP-4144722-A1 COMPOUND AS UBR BOX DOMAIN LIGAND Autotac Inc. (KR) 2023-03-08 EP disclosed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND UBR4, UBQLN2, UBTF KAT6A 1150/4885GFER 2489/4885KMT2A 1391/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.