Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | UBE2N | P61088 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.68 |
| ▸ | APP | P05067 | 7/20 | 0.62 |
| ▸ | ACHE | P22303 | 6/20 | 0.62 |
| ▸ | BCHE | P06276 | 5/20 | 0.62 |
| ▸ | PDE5A | O76074 | 3/20 | 0.58 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21118626 | 0.91 | ACHE (0.59) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL2590769 | 0.90 | RAD52 (0.68) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL21055802 | 0.89 | PDE5A (0.76) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL2590671 | 0.87 | RAD52 (0.82) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL2587383 | 0.86 | RAD52 (0.76) | RAD52PKMKDM4EALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL3636898 | 0.86 | KDM4E (0.83) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL16280938 | 0.85 | RAD52 (0.79) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL28805458 | 0.85 | PDE5A (0.76) | ALDH1A1LMNAMAPTKMT2APDE5A | |
| SCHEMBL12175837 | 0.83 | RAD52 (1.00) | RAD52PKMKDM4EALDH1A1LMNA | |
| SCHEMBL2590399 | 0.83 | RAD52 (0.70) | RAD52PKMKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |