Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.31 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261225 | 0.73 | KMT2A (0.35) | HSP90AA1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL2585675 | 0.63 | ALDH1A1 (0.46) | HSP90AA1SMN1; SMN2NPC1RAB9ATP53 | |
| SCHEMBL13871538 | 0.61 | CNR2 (0.52) | TDP1SIGMAR1EPHX2SMN1; SMN2NPC1 | |
| SCHEMBL10216805 | 0.61 | CNR2 (0.52) | TDP1SIGMAR1EPHX2SMN1; SMN2NPC1 | |
| SCHEMBL16301132 | 0.61 | TDP1 (0.55) | TDP1SIGMAR1EPHX2NAMPTNR1H2 | |
| SCHEMBL2895322 | 0.60 | TDP1 (0.64) | TDP1SIGMAR1EPHX2NR1H2NR1H3 | |
| SCHEMBL2895326 | 0.60 | TDP1 (0.64) | TDP1SIGMAR1EPHX2NR1H2NR1H3 | |
| SCHEMBL2895324 | 0.60 | TDP1 (0.64) | TDP1SIGMAR1EPHX2NR1H2NR1H3 | |
| SCHEMBL172785 | 0.60 | TDP1 (0.60) | TDP1SIGMAR1EPHX2NR1H2NR1H3 | |
| SCHEMBL944228 | 0.60 | TDP1 (0.60) | TDP1SIGMAR1EPHX2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |