Difenamizole

Difenamizole

SCHEMBL25873

CC(C(=O)Nc1cc(-c2ccccc2)nn1-c1ccccc1)N(C)C

nearest known ligand 0.62

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 8/20 0.62
TP53 P04637 1/20 0.61
MAPT P10636 2/20 0.59
LMNA P02545 2/20 0.59
ALDH1A1 P00352 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.57
SOAT2 O75908 2/20 0.56
SOAT1 P35610 2/20 0.56
NTRK1 P04629 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Difenamizole SCHEMBL1651121 0.98 GRM5 (0.59) GRM5TP53MAPTLMNAALDH1A1
SCHEMBL3176234 0.87 GRM5 (0.67) GRM5TP53MAPTLMNAALDH1A1
SCHEMBL8289183 0.78 GRM5 (0.72) GRM5MAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL2482825 0.77 GRM5 (1.00) GRM5LMNA
SCHEMBL14133258 0.76 PTPN1 (0.83) GRM5MAPTLMNAALDH1A1NTRK1
SCHEMBL15070769 0.73 MAPT (0.75) GRM5MAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL14133182 0.73 MAPT (0.79) GRM5MAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL5924123 0.72 GRM5 (1.00) GRM5MAPTLMNAALDH1A1NTRK1
SCHEMBL14132521 0.72 MAPT (0.77) GRM5MAPTLMNAALDH1A1SMN1; SMN2
SCHEMBL11471937 0.72 GRM5 (0.64) GRM5MAPTLMNAALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2218 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118684620-A Betel nut alkaloid and preparation method and application thereof 暨南大学 2024-09-24 CN claimed
US-20240041935-A1 PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS CREATIVE MEDICAL TECHNOLOGIES, INC. (US) 2024-02-08 US claimed
CN-117170426-A Temperature control system for measuring chemical stability of energetic material 西安军潮机电设备有限公司 2023-12-05 CN claimed
WO-2021054927-A2 GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS SOUTH DAKOTA BOARD OF REGENTS (US) 2021-03-25 WO claimed
EP-3691658-A2 IMMUNOMODULATORY OLIGOSACCHARIDES The Regents of The University of California (US) 2020-08-12 EP claimed
US-20200048305-A1 GLUTATHIONE-CHOLESTEROL DERIVATIVES AS BRAIN TARGETING AGENTS SOUTH DAKOTA BOARD OF REGENTS (US) 2020-02-13 US claimed
WO-2019071021-A2 IMMUNOMODULATORY OLIGOSACCHARIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-04-11 WO claimed
US-9622969-B2 Polymer conjugated protein micelles SOUTH DAKOTA STATE UNIV (US) 2017-04-18 US claimed
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
US-20140370110-A1 POLYMER CONJUGATED PROTEIN MICELLES SOUTH DAKOTA STATE UNIVERSITY (US) 2014-12-18 US claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
EP-0786999-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1999-01-20 EP claimed
EP-0792371-A4 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO INC (US) 1998-12-30 EP claimed
EP-0792371-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-09-03 EP claimed
EP-0786999-A1 COMBINATION METHOD FOR ACNE TREATMENT Merck & Co., Inc. (US) 1997-08-06 EP claimed
US-5543417-A 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent MERCK & CO., INC. (US) 1996-08-06 US claimed
WO-1996012487-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed
WO-1996012817-A1 COMBINATION METHOD FOR ACNE TREATMENT MERCK & CO., INC. (US) 1996-05-02 WO claimed