Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.64 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.64 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.64 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482825 | 0.84 | GRM5 (1.00) | GRM5LMNA | |
| SCHEMBL14133258 | 0.83 | PTPN1 (0.83) | GRM5MAPTLMNAALDH1A1KCNJ6 | |
| SCHEMBL3176234 | 0.82 | GRM5 (0.67) | GRM5MAPTLMNAALDH1A1NTRK1 | |
| SCHEMBL5924123 | 0.80 | GRM5 (1.00) | GRM5MAPTLMNAALDH1A1NTRK1 | |
| SCHEMBL11471937 | 0.79 | GRM5 (0.64) | GRM5MAPTLMNAALDH1A1NTRK1 | |
| SCHEMBL5924170 | 0.79 | GRM5 (1.00) | GRM5LMNA | |
| SCHEMBL15070769 | 0.78 | MAPT (0.75) | GRM5MAPTLMNAALDH1A1NTRK1 | |
| SCHEMBL14133182 | 0.78 | MAPT (0.79) | GRM5MAPTLMNAALDH1A1KCNJ6 | |
| Difenamizole SCHEMBL25873 | 0.78 | GRM5 (0.62) | GRM5MAPTLMNAALDH1A1NTRK1 | |
| SCHEMBL5924283 | 0.78 | GRM5 (1.00) | GRM5MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030128-A2 | PYRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2005-04-07 | — | — | WO | disclosed |