Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29846416 | 0.86 | EZH2 (0.51) | EZH2KDM4ECYP11B2ALDH1A1L3MBTL1 | |
| SCHEMBL2594393 | 0.86 | EZH2 (0.51) | EZH2KDM4ECYP11B2ALDH1A1L3MBTL1 | |
| SCHEMBL15687571 | 0.82 | CYP11B2 (0.56) | EZH2KDM4ECYP11B2ALDH1A1GAA | |
| SCHEMBL28264532 | 0.81 | EZH2 (0.47) | EZH2PARP1KDM4ECYP11B2GCK | |
| SCHEMBL28686269 | 0.77 | EZH2 (0.57) | EZH2TRPV1 | |
| SCHEMBL29506803 | 0.77 | EZH2 (0.57) | EZH2TRPV1 | |
| SCHEMBL4953281 | 0.76 | EZH2 (0.41) | EZH2KDM4ECYP11B2PARP2TRPV1 | |
| SCHEMBL26956221 | 0.76 | DDB1 (0.42) | EZH2KDM4ECYP11B2ALDH1A1TRPV1 | |
| SCHEMBL1695067 | 0.75 | EZH2 (0.50) | EZH2TLR8TYK2KDM4EL3MBTL1 | |
| SCHEMBL21140432 | 0.74 | CYP11B1 (0.47) | EZH2CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566328-A1 | INDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |