SCHEMBL25875455

SCHEMBL25875455

Nc1nc(O)c2ncn(CCCC(=O)O)c2n1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.50
CSNK2A2 P19784 1/20 0.49
CSNK2A1 P68400 1/20 0.49
ADCY5 O95622 3/20 0.44
HPRT1 P00492 4/20 0.43
CCNE1 P24864 3/20 0.42
CDK2 P24941 3/20 0.42
CDK1 P06493 2/20 0.42
CCNB1 P14635 2/20 0.42
TK1 P04183 1/20 0.42
HSD17B10 Q99714 1/20 0.41
TLR9 Q9NR96 1/20 0.41
TLR7 Q9NYK1 1/20 0.41
ADORA2A P29274 1/20 0.41
PIK3R1 P27986 1/20 0.39
PIK3CA P42336 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14595245 0.83 ADORA2A (0.56) CYP2C19CSNK2A2CSNK2A1HPRT1CCNE1
SCHEMBL14595281 0.82 TK1 (0.58) CYP2C19HPRT1CCNE1CDK2CDK1
SCHEMBL22348820 0.80 CCNE1 (0.52) CYP2C19HPRT1CCNE1CDK2CDK1
SCHEMBL7388886 0.79 CCNE1 (0.59) CYP2C19ADCY5HPRT1CCNE1CDK2
SCHEMBL7271581 0.76 CCNE1 (0.44) CYP2C19CCNE1CDK2CDK1CCNB1
SCHEMBL7271567 0.76 CCNE1 (0.44) CYP2C19CCNE1CDK2CDK1CCNB1
SCHEMBL17860490 0.75 CCNE1 (0.71) CYP2C19CCNE1CDK2CDK1CCNB1
SCHEMBL17297723 0.75 ADCY5 (0.74) ADCY5ADORA2A
SCHEMBL20577001 0.74 CCNE1 (0.45) CYP2C19CCNE1CDK2CDK1CCNB1
Penciclovir SCHEMBL29357169 0.74 CCNE1 (0.46) CYP2C19CCNE1CDK2CDK1CCNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3630795-B1 ENGINEERED ALDOLASE POLYPEPTIDES AND USES THEREOF ENZYMASTER NINGBO BIO ENG CO LTD (CN) 2023-07-26 EP disclosed