Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25875888 | 0.85 | MAOA (0.53) | HDAC3HDAC1HDAC2JAK2ROCK2 | |
| SCHEMBL22751973 | 0.80 | JAK2 (0.69) | JAK2ROCK2ROCK1JAK3IKBKB | |
| SCHEMBL25875964 | 0.79 | JAK2 (0.50) | EPHX1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL25875889 | 0.79 | JAK2 (0.55) | HDAC3HDAC1HDAC2JAK2ROCK2 | |
| SCHEMBL25875931 | 0.78 | JAK2 (0.49) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL22857527 | 0.78 | JAK2 (0.75) | NAMPTJAK2ROCK2ROCK1JAK3 | |
| SCHEMBL22751869 | 0.78 | JAK2 (0.75) | NAMPTJAK2ROCK2ROCK1JAK3 | |
| SCHEMBL22751938 | 0.78 | JAK2 (0.75) | NAMPTJAK2ROCK2ROCK1JAK3 | |
| SCHEMBL22857549 | 0.78 | JAK2 (0.75) | NAMPTJAK2ROCK2ROCK1JAK3 | |
| SCHEMBL22752014 | 0.78 | JAK2 (0.75) | NAMPTJAK2ROCK2ROCK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227430-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227430-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, CHUK, MAP3K2 | EPHX1 3460/4885HDAC3 1221/4885HDAC4 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.