Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 9/20 | 0.55 |
| ▸ | JAK2 | O60674 | 8/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.55 |
| ▸ | JAK3 | P52333 | 7/20 | 0.55 |
| ▸ | IKBKB | O14920 | 5/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25875889 | 0.81 | JAK2 (0.55) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL25875914 | 0.79 | JAK2 (0.53) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL22752095 | 0.78 | ROCK2 (0.79) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL2162409 | 0.78 | ROCK2 (0.75) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL22751970 | 0.77 | JAK2 (0.77) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL22752100 | 0.77 | JAK2 (0.77) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL2164132 | 0.76 | ROCK2 (0.69) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL21845791 | 0.76 | JAK2 (0.71) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL25875929 | 0.75 | JAK2 (0.49) | ROCK1JAK2ROCK2JAK3IKBKB | |
| SCHEMBL25478350 | 0.75 | DEGS1 (0.68) | ROCK1JAK2ROCK2JAK3SCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227430-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | ALCON INC. (CH) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227430-A1 | ARYL CYCLOPROPYL-AMINO-ISOQUINOLINYL AMIDE COMPOUNDS | UACA, CHUK, MAP3K2 | ROCK1 347/4885JAK2 822/4885ROCK2 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.