Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.31 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25876233 | 0.89 | MAT2A (0.33) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25875942 | 0.89 | MAT2A (0.42) | MAT2APDE4BLRRK2 | |
| SCHEMBL25876299 | 0.87 | LRRK2 (0.36) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25876077 | 0.87 | MERTK (0.35) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25876275 | 0.87 | PDE1A (0.36) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25876041 | 0.86 | MAT2A (0.35) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25875863 | 0.83 | PDE2A (0.41) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL25876131 | 0.82 | PDE9A (0.34) | PDE10A | |
| SCHEMBL25875902 | 0.82 | DGAT1 (0.33) | MAT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL25876051 | 0.80 | PDE9A (0.35) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | TYK MEDICINES, INC. (CN) | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234954-A1 | COMPOUND USED AS RET KINASE INHIBITOR AND APPLICATION THEREOF | RET, ROR1, FGFR3 | MAT2A 686/4885ADORA1 2370/4885PDE4A 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.