SCHEMBL2587802

SCHEMBL2587802

Nc1ccc(C(=O)Nc2ccc(O)cc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.85
TDP1 Q9NUW8 2/20 0.85
MEN1 O00255 1/20 0.85
LMNA P02545 1/20 0.85
PKM P14618 1/20 0.85
APEX1 P27695 1/20 0.85
KMT2A Q03164 1/20 0.85
PTGS1 P23219 2/20 0.67
CA12 O43570 1/20 0.65
CA1 P00915 1/20 0.65
CA2 P00918 1/20 0.65
CA9 Q16790 1/20 0.65
DEGS1 O15121 3/20 0.64
SNCA P37840 2/20 0.64
MAPT P10636 3/20 0.63
NQO2 P16083 2/20 0.61
RAB9A P51151 2/20 0.59
NPC1 O15118 1/20 0.59
TP53 P04637 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8439715 1.00 POLB (0.85) POLBTDP1MEN1LMNAPKM
SCHEMBL30319980 0.92 POLB (1.00) POLBTDP1MEN1LMNAPKM
SCHEMBL1353478 0.92 POLB (1.00) POLBTDP1MEN1LMNAPKM
SCHEMBL137276 0.92 POLB (1.00) POLBTDP1MEN1LMNAPKM
SCHEMBL2128727 0.92 POLB (1.00) POLBTDP1MEN1LMNAPKM
SCHEMBL9681496 0.92 POLB (1.00) POLBTDP1MEN1LMNAPKM
SCHEMBL8442129 0.90 POLB (0.96) POLBTDP1MEN1LMNAPKM
Hydrochloric Acid SCHEMBL8640632 0.90 POLB (0.96) POLBTDP1MEN1LMNAPKM
SCHEMBL900928 0.90 DEGS1 (0.75) POLBTDP1MEN1LMNAPKM
SCHEMBL8420639 0.90 DEGS1 (0.75) POLBTDP1MEN1LMNAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8664341-B2 Vinylbenzyl ethers of polycyclopentadiene polyphenol DOW GLOBAL TECHNOLOGIES, LLC (US) 2014-03-04 US disclosed
US-8519066-B2 Poly(allyl ethers) of polycyclopentadiene polyphenol DOW GLOBAL TECHNOLOGIES LLC (US) 2013-08-27 US disclosed
US-20130211015-A1 VINYLBENZYL ETHERS OF POLYCYCLOPENTADIENE POLYPHENOL DOW GLOBAL TECHNOLOGIES LLC (US) 2013-08-15 US disclosed
EP-2563756-A1 POLY(ALLYL ETHER)S OF POLYCYCLOPENTADIENE POLYPHENOL Dow Global Technologies LLC (US) 2013-03-06 EP disclosed
EP-2563755-A1 VINYLBENZYL ETHERS OF POLYCYCLOPENTADIENE POLYPHENOL Dow Global Technologies LLC (US) 2013-03-06 EP disclosed
US-20130041114-A1 POLY(ALLYL ETHERS) OF POLYCYCLOPENTADIENE POLYPHENOL DOW GLOBAL TECHNOLOGIES LLC (US) 2013-02-14 US disclosed
WO-2011136847-A1 POLY(ALLYL ETHER)S OF POLYCYCLOPENTADIENE POLYPHENOL DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-03 WO disclosed
WO-2011136845-A1 VINYLBENZYL ETHERS OF POLYCYCLOPENTADIENE POLYPHENOL DOW GLOBAL TECHNOLOGIES LLC (US) 2011-11-03 WO disclosed
US-20090176773-A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction FORSCHUNGSVERBUND BERLIN E.V. (DE) 2009-07-09 US disclosed
US-20090176773-A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction FORSCHUNGSVERBUND BERLIN E.V. (DE) 2009-07-09 US disclosed
EP-0409069-B1 Mesogenic polycyanates and polycyanamides and thermosets thereof DOW CHEMICAL CO (US) 1999-06-02 EP disclosed
US-5612479-A Polyphenols containing mesogenic moieties as lateral substituents THE DOW CHEMICAL COMPANY (US) 1997-03-18 US disclosed
US-5470946-A Products resulting from polymerizing or curing polycyanates containing mesogenic moieties as lateral substituents THE DOW CHEMICAL COMPANY (US) 1995-11-28 US disclosed
US-5442039-A Rod-like mesogenic structures incorporated into polytriazine products; improved tensile strength, flexural strength THE DOW CHEMICAL COMPANY (US) 1995-08-15 US disclosed
US-5428125-A Liquid crystalline THE DOW CHEMICAL COMPANY (US) 1995-06-27 US disclosed
US-5206321-A Polycyanates containing mesogenic moieties as lateral substituents THE DOW CHEMICAL COMPANY (US) 1993-04-27 US disclosed
EP-0409069-A2 Mesogenic polycyanates and thermosets thereof THE DOW CHEMICAL COMPANY (US) 1991-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176773-A1 Non-Peptidic Inhibitors of AKAP/PKA Interaction PRKCH, AIP, PRKCE POLB 4651/4885TDP1 3383/4885MEN1 4118/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.