Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 11/20 | 0.57 |
| ▸ | GSK3B | P49841 | 11/20 | 0.57 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25883208 | 0.84 | GSK3A (0.58) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL670431 | 0.83 | KDM4E (0.62) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL29484634 | 0.83 | AURKA (0.59) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL4768433 | 0.82 | GSK3A (0.54) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL5598434 | 0.80 | JAK2 (0.57) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL29466293 | 0.80 | MAPK8 (0.60) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL4213995 | 0.80 | GSK3B (0.56) | GSK3AGSK3BAURKANPC1CDK2 | |
| SCHEMBL4228636 | 0.80 | GSK3B (0.45) | GSK3AGSK3BAURKAMAPTAURKB | |
| SCHEMBL4186091 | 0.79 | AURKA (0.51) | GSK3AGSK3BAURKAPRKCDMAPT | |
| SCHEMBL4369472 | 0.79 | RAB9A (0.47) | GSK3AGSK3BAURKAMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215526-A1 | CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF | Shanghai Pharmaceuticals Holding Co., Ltd. (CN) | 2023-07-26 | — | — | EP | disclosed |