Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21314229 | 0.88 | HTT (0.39) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL2589600 | 0.86 | NPC1 (0.43) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL2580908 | 0.85 | NPC1 (0.35) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL9408821 | 0.83 | NPC1 (0.56) | NPC1RAB9AMAPTKDM4EATM | |
| SCHEMBL1100125 | 0.82 | NPC1 (0.39) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL12199840 | 0.82 | CA1 (0.48) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL9100960 | 0.81 | CACNA1D (0.39) | NPC1RAB9AKDM4EGAAALDH1A1 | |
| SCHEMBL9408759 | 0.80 | NPC1 (0.40) | NPC1RAB9AMAPTKDM4EATM | |
| SCHEMBL9638513 | 0.77 | TRIM24 (0.42) | NPC1RAB9AABL1ABCB1BCR | |
| SCHEMBL29492118 | 0.77 | TRIM24 (0.42) | NPC1RAB9AABL1ABCB1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564245-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | Novartis AG (CH) | 2013-03-06 | — | — | EP | claimed |
| WO-2011137142-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | claimed |
| EP-3052534-A1 | METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES | Novartis AG (CH) | 2016-08-10 | — | — | EP | disclosed |
| WO-2015048035-A1 | METHOD FOR MAKING UV-ABSORBING OPHTHALMIC LENSES | NOVARTIS AG (CH) | 2015-04-02 | — | — | WO | disclosed |
| EP-2564245-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | Novartis AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011137142-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | disclosed |