Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | RAB9A | P51151 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21314229 | 0.89 | HTT (0.39) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13412683 | 0.86 | NPC1 (0.46) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2587974 | 0.86 | NPC1 (0.40) | NPC1RAB9ALMNAALDH1A1KDM4E | |
| SCHEMBL2580908 | 0.86 | NPC1 (0.35) | NPC1RAB9ALMNAPOLBKDM4E | |
| SCHEMBL9100960 | 0.83 | CACNA1D (0.39) | NPC1RAB9AALDH1A1POLBKDM4E | |
| SCHEMBL1099556 | 0.82 | NPC1 (0.42) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL564179 | 0.80 | RAB9A (0.61) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29814623 | 0.80 | RAB9A (0.61) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL13483389 | 0.78 | NPC1 (0.39) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL1100680 | 0.76 | NPC1 (0.37) | NPC1RAB9ALMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2564245-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | Novartis AG (CH) | 2013-03-06 | — | — | EP | claimed |
| WO-2011137142-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | claimed |
| EP-3390498-B1 | HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF | ALCON INC (CH) | 2021-05-26 | — | — | EP | disclosed |
| EP-2564245-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | Novartis AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011137142-A1 | INTRAOCULAR LENSES WITH COMBINATIONS OF UV ABSORBERS AND BLUE LIGHT CHROMOPHORES | NOVARTIS AG (CH) | 2011-11-03 | — | — | WO | disclosed |