Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25368730 | 0.84 | RAB9A (0.49) | MAPTLMNAKMT2ASMN1; SMN2DYRK1A | |
| SCHEMBL30040343 | 0.81 | MAPT (0.64) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL25219141 | 0.81 | MAPT (0.64) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL6983750 | 0.79 | DYRK1A (0.61) | RAD52MAPTKDM4EMEN1TNF | |
| SCHEMBL14020422 | 0.79 | HSD17B1 (0.57) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL3644141 | 0.77 | PDPK1 (0.55) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL2656824 | 0.76 | GFER (0.57) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL30770326 | 0.76 | GFER (0.57) | MAPTKDM4EMEN1TNFLMNA | |
| SCHEMBL159986 | 0.76 | CLK1 (0.60) | LMNADYRK1ATRPM8 | |
| SCHEMBL6656001 | 0.75 | MAPT (0.65) | RAD52MAPTKDM4EMEN1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566858-A2 | HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS | Pfizer Inc. (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138751-A2 | HETEROCYCLIC DERIVATIVES AS ALK INHIBITORS | PFIZER INC. (US) | 2011-11-10 | — | — | WO | disclosed |