Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15850536 | 0.88 | ALDH1A1 (0.39) | APLNR | |
| SCHEMBL21134909 | 0.87 | APLNR (0.32) | APLNR | |
| SCHEMBL19466298 | 0.87 | APLNR (0.32) | APLNR | |
| SCHEMBL12345276 | 0.79 | — | — | |
| SCHEMBL15870610 | 0.78 | — | — | |
| SCHEMBL15870609 | 0.78 | — | — | |
| SCHEMBL5987418 | 0.78 | — | — | |
| SCHEMBL19466297 | 0.77 | APLNR (0.32) | APLNR | |
| SCHEMBL4940146 | 0.76 | ACE (0.35) | APLNR | |
| SCHEMBL14274192 | 0.73 | ATM (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014072640-A1 | NOVEL METHOD FOR SYNTHESISING (2E)-3-(3,4-DIMETHOXYPHENYL)PROP-2-ENENITRILE, AND APPLICATION TO THE SYNTHESIS OF IVABRADINE AND THE ADDITION SALTS OF SAME WITH A PHARMACEUTICALLY ACCEPTABLE ACID | LES LABORATOIRES SERVIER (FR) | 2014-05-15 | — | — | WO | disclosed |
| EP-2566850-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE SALTS | Richter Gedeon Nyrt. (HU) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138625-A1 | INDUSTRIAL PROCESS FOR THE SYNTHESIS OF IVABRADINE SALTS | RICHTER GEDEON NYRT. (HU) | 2011-11-10 | — | — | WO | disclosed |