⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376686 | 0.81 | PIK3CD (0.70) | — | |
| SCHEMBL12244050 | 0.79 | PIK3CD (0.44) | — | |
| SCHEMBL18478122 | 0.73 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL12428090 | 0.73 | SMN1; SMN2 (0.41) | — | |
| SCHEMBL13218350 | 0.73 | FAP (0.42) | — | |
| SCHEMBL8234453 | 0.73 | FAP (0.42) | — | |
| SCHEMBL13532952 | 0.73 | FAP (0.42) | — | |
| SCHEMBL5851955 | 0.72 | MMP2 (0.33) | — | |
| SCHEMBL7897243 | 0.72 | CHRM2 (0.42) | — | |
| SCHEMBL15423481 | 0.70 | ATM (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739074-B2 | Ras inhibitors | Revolution Medicines, Inc. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |
| US-20230233569-A1 | METHODS FOR DELAYING, PREVENTING, AND TREATING ACQUIRED RESISTANCE TO RAS INHIBITORS | WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT | 2023-07-27 | — | — | US | disclosed |