⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30703392 | 1.00 | — | — | |
| SCHEMBL25897346 | 0.73 | DRD4 (0.33) | — | |
| SCHEMBL25429843 | 0.71 | ADRA2A (0.37) | — | |
| SCHEMBL30703405 | 0.71 | ADRA2A (0.37) | — | |
| SCHEMBL25897342 | 0.68 | HIF1A (0.35) | — | |
| SCHEMBL29766636 | 0.68 | HIF1A (0.35) | — | |
| SCHEMBL11622939 | 0.62 | DCUN1D1 (0.41) | — | |
| SCHEMBL25897386 | 0.60 | PBRM1 (0.30) | — | |
| SCHEMBL31110713 | 0.59 | NFKB1 (0.31) | — | |
| SCHEMBL31110769 | 0.59 | PBRM1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242546-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | SUDO BIOSCIENCES LIMITED (GB) | 2023-08-03 | — | — | US | disclosed |
| US-20230242546-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | SUDO BIOSCIENCES LIMITED (GB) | 2023-08-03 | — | — | US | disclosed |