Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25897799 | 0.86 | TIPARP (0.41) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL25897917 | 0.85 | TLR8 (0.42) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL25898806 | 0.80 | LMNA (0.40) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL25897855 | 0.79 | LMNA (0.39) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL26786834 | 0.77 | LMNA (0.38) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL25897832 | 0.77 | TIPARP (0.49) | TLR8SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL25898722 | 0.77 | GRM2 (0.39) | SMN1; SMN2LMNAKDM4EGRM2TSHR | |
| SCHEMBL25320799 | 0.77 | TIPARP (0.60) | — | |
| SCHEMBL25320803 | 0.77 | TIPARP (0.60) | — | |
| SCHEMBL25898542 | 0.76 | TIPARP (0.48) | TLR8SMN1; SMN2LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |