Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 6/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 3/20 | 0.36 |
| ▸ | SIK1 | P57059 | 1/20 | 0.35 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.35 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25897832 | 0.88 | TIPARP (0.49) | TIPARPTLR8LMNAHTTKDM4E | |
| SCHEMBL25898373 | 0.88 | NPC1 (0.40) | TIPARPTLR8KDM4ESMN1; SMN2TNF | |
| SCHEMBL25898542 | 0.87 | TIPARP (0.48) | TIPARPTLR8LMNAHTTKDM4E | |
| SCHEMBL25897886 | 0.86 | TLR8 (0.42) | TLR8LMNAHTTKDM4EMAPT | |
| SCHEMBL26793446 | 0.85 | TIPARP (0.49) | TIPARPLMNAHTTKDM4EMAPT | |
| SCHEMBL25898806 | 0.84 | LMNA (0.40) | TLR8LMNAHTTKDM4EMAPT | |
| SCHEMBL25898836 | 0.84 | DDR1 (0.42) | TLR8KDM4ESMN1; SMN2CNR2TNF | |
| SCHEMBL25898407 | 0.84 | TIPARP (0.48) | TIPARPTNFGRM2HDAC3HDAC1 | |
| SCHEMBL25899773 | 0.84 | TIPARP (0.44) | TIPARPTLR8LMNAHTTKDM4E | |
| SCHEMBL25898742 | 0.84 | TIPARP (0.46) | TIPARPTLR8LMNAHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023147418-A1 | PARP7 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |