Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 5/20 | 0.36 |
| ▸ | NOS2 | P35228 | 5/20 | 0.36 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | CFB | P00751 | 5/20 | 0.35 |
| ▸ | DHFR | P00374 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737415 | 0.80 | AXL (0.47) | AXLPRKCICFBMAP4K4AURKA | |
| SCHEMBL18479114 | 0.77 | AXL (0.53) | AXLPRKCICFBDYRK1ACCR1 | |
| SCHEMBL22509925 | 0.77 | NUDT1 (0.37) | AXLPRKCIMAP4K4AURKADAPK3 | |
| SCHEMBL30110643 | 0.77 | AXL (0.53) | AXLPRKCICFBDYRK1ACCR1 | |
| SCHEMBL6127940 | 0.74 | AXL (0.42) | AXLPRKCICFBJAK3BTK | |
| SCHEMBL2628910 | 0.74 | AXL (0.42) | AXLPRKCICFBCCNKCDK12 | |
| SCHEMBL28645695 | 0.73 | CSNK1A1 (0.40) | KDM4EALDH1A1GAAJAK2KDR | |
| SCHEMBL2628879 | 0.72 | PRKCI (0.47) | AXLPRKCICFBKDM4EALDH1A1 | |
| SCHEMBL14040931 | 0.71 | NUDT1 (0.54) | KDM4EALDH1A1HPGDJAK3 | |
| SCHEMBL25898919 | 0.71 | RET (0.47) | NOS3NOS2NOS1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146991-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |