Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.42 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25898919 | 0.84 | RET (0.47) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL25926176 | 0.77 | RET (0.40) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL21579418 | 0.72 | RET (0.47) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL30515856 | 0.72 | RET (0.47) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL15717018 | 0.72 | MAPT (0.52) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL25899116 | 0.71 | HTT (0.42) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL6127809 | 0.70 | MAPT (0.48) | MAPTXDHNOS1HTTPTK2 | |
| SCHEMBL15669999 | 0.69 | HTT (0.41) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL1482228 | 0.69 | RET (0.44) | MAPTRETPI4KAXDHLRRK2 | |
| SCHEMBL20176891 | 0.68 | KDM4E (0.45) | MAPTRETPI4KAXDHLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |