Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.38 |
| ▸ | MARK3 | P27448 | 2/20 | 0.34 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MYC | P01106 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 2/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2583359 | 0.77 | CYP19A1 (0.38) | CYP19A1MAPTOPRM1OPRD1OPRK1 | |
| SCHEMBL1150372 | 0.75 | EGLN1 (0.42) | MARK3KDM4ENPSR1ALDH1A1MGLL | |
| SCHEMBL8687319 | 0.72 | LMNA (0.35) | MAPTKDM4ELMNAMEN1ALDH1A1 | |
| SCHEMBL2581394 | 0.69 | SCN9A (0.35) | MAPTOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2587677 | 0.69 | PTPRC (0.42) | CYP19A1MAPTKDM4ELMNANPSR1 | |
| SCHEMBL8654708 | 0.69 | ALDH1A1 (0.40) | MARK3NPSR1ALDH1A1KMT2A | |
| SCHEMBL2342685 | 0.66 | ELANE (0.48) | MARK3MAPTKDM4EALDH1A1KAT2B | |
| SCHEMBL9470123 | 0.64 | MARK3 (0.51) | MARK3MARK4ALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL2579627 | 0.63 | ALDH1A1 (0.42) | CYP19A1MAPTKDM4ELMNANPSR1 | |
| SCHEMBL23257662 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269788-A1 | SPIRO-OXINDOLE-DERIVATIVES AS SODIUM CHANNEL BLOCKERS | XENON PHARMACEUTICALS INC. (CA) | 2011-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269788-A1 | SPIRO-OXINDOLE-DERIVATIVES AS SODIUM CHANNEL BLOCKERS | SCN3A, SCN1B, SCN2B | CYP19A1 2899/4885MARK3 852/4885MARK4 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.