SCHEMBL2590178

SCHEMBL2590178

O=C(O)CCN1C(=O)C2C3C=CC(O3)C2C1=O

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.61
ALDH1A1 P00352 6/20 0.50
PKM P14618 2/20 0.47
ATM Q13315 2/20 0.45
KDM4E B2RXH2 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
OPRM1 P35372 1/20 0.40
OPRD1 P41143 1/20 0.40
OPRK1 P41145 1/20 0.40
MAPT P10636 1/20 0.39
HPGD P15428 1/20 0.39
HTT P42858 1/20 0.39
CACNA1B Q00975 1/20 0.39
APBA1 Q02410 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15043610 1.00 MAPK1 (0.61) MAPK1ALDH1A1PKMATMKDM4E
SCHEMBL21614012 0.90 MAPK1 (0.50) MAPK1ALDH1A1PKMATMHTT
SCHEMBL23451376 0.90 MAPK1 (0.50) MAPK1ALDH1A1PKMATMHTT
SCHEMBL17232606 0.85 MAPK1 (0.47) MAPK1ALDH1A1PKMATMOPRM1
SCHEMBL14719123 0.85 MAPK1 (0.47) MAPK1ALDH1A1PKMATMOPRM1
SCHEMBL12182019 0.85 ALDH1A1 (0.46) MAPK1ALDH1A1PKMATMOPRM1
SCHEMBL18908594 0.83 ALDH1A1 (0.45) MAPK1ALDH1A1PKMATML3MBTL1
SCHEMBL6266653 0.82 SMN1; SMN2 (0.59) MAPK1ALDH1A1PKMATMSMN1; SMN2
SCHEMBL10126634 0.81 MAPK1 (0.43) MAPK1ALDH1A1PKMATMOPRM1
SCHEMBL12287188 0.81 MAPK1 (0.43) MAPK1ALDH1A1PKMATMOPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210198410-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2021-07-01 US disclosed
US-20200330383-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-10-22 US disclosed
US-20200333350-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-10-22 US disclosed
US-20200325265-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2020-10-15 US disclosed
EP-3345944-B1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF UNIV TEXAS (US) 2020-03-18 EP disclosed
EP-3345944-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF The Board of Regents of The University of Texas System (US) 2018-07-11 EP disclosed
US-10017598-B2 Block copolymer and micelle compositions and methods of use thereof THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-07-10 US disclosed
US-9872926-B2 Multicolored pH-activatable fluorescence nanoplatform THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-01-23 US disclosed
US-9872926-B2 Multicolored pH-activatable fluorescence nanoplatform THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-01-23 US disclosed
US-20170320993-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2017-11-09 US disclosed
WO-2013152059-A1 MULTICOLORED PH-ACTIVATABLE FLUORESCENCE NANOPLATFORM THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-10-10 WO disclosed
US-20130142763-A1 CROSSLINKED CELLULOSIC POLYMERS EMPIRE TECHNOLOGY DEVELOPMENT LLC (US) 2013-06-06 US disclosed
EP-2569081-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME Air Products and Chemicals, Inc. (US) 2013-03-20 EP disclosed
US-20130047844-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2013-02-28 US disclosed
US-20130047844-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2013-02-28 US disclosed
WO-2011143530-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2011-11-17 WO disclosed
US-7749408-B2 Electro-optic dendrimer-based glass composites UNIVERSITY OF WASHINGTON (US) 2010-07-06 US disclosed
US-7749408-B2 Electro-optic dendrimer-based glass composites UNIVERSITY OF WASHINGTON (US) 2010-07-06 US disclosed
US-20070152198-A1 ELECTRO-OPTIC DENDRIMER-BASED GLASS COMPOSITES WASHINGTON, UNIVERSITY OF (US) 2007-07-05 US disclosed
US-20070152198-A1 ELECTRO-OPTIC DENDRIMER-BASED GLASS COMPOSITES WASHINGTON, UNIVERSITY OF (US) 2007-07-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170320993-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF FOLR2, FOLR1, MPC2 MAPK1 4049/4885ALDH1A1 3441/4885PKM 406/4885
US-20200330383-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF FOLR2, FOLR1, MPC2 MAPK1 4049/4885ALDH1A1 3441/4885PKM 406/4885
US-10017598-B2 Block copolymer and micelle compositions and methods of use thereof FOLR2, FOLR1, MPC2 MAPK1 4017/4885ALDH1A1 3141/4885PKM 477/4885
US-20210198410-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF FOLR2, FOLR1, MPC2 MAPK1 4049/4885ALDH1A1 3441/4885PKM 406/4885
US-20200325265-A1 NOVEL BLOCK COPOLYMER AND MICELLE COMPOSITIONS AND METHODS OF USE THEREOF FOLR2, FOLR1, MPC2 MAPK1 4049/4885ALDH1A1 3441/4885PKM 406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.