Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 2/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP13 | P45452 | 2/20 | 0.30 |
| ▸ | MMP14 | P50281 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23588914 | 0.90 | HDAC2 (0.37) | HSD11B1USP2HDAC2HDAC1DRD2 | |
| SCHEMBL23588941 | 0.90 | USP2 (0.40) | HSD11B1USP2HDAC2HDAC1DRD2 | |
| SCHEMBL23588704 | 0.89 | HDAC2 (0.37) | HSD11B1USP2HDAC2HDAC1DRD2 | |
| SCHEMBL19977411 | 0.89 | DRD2 (0.37) | USP2DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL25001376 | 0.86 | HSD11B1 (0.38) | HSD11B1HDAC2HDAC1DRD2DRD3 | |
| SCHEMBL24920438 | 0.83 | DRD2 (0.34) | DRD2DRD3KDM4EALDH1A1MAPT | |
| SCHEMBL24921699 | 0.83 | DRD2 (0.34) | USP2DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL23589026 | 0.82 | USP2 (0.37) | HSD11B1USP2HDAC2HDAC1KDM4E | |
| SCHEMBL23589140 | 0.82 | HDAC2 (0.40) | HSD11B1USP2HDAC2HDAC1DRD2 | |
| SCHEMBL24855098 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |