Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL574153 | 0.89 | NPC1 (0.46) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL709631 | 0.81 | NPC1 (0.41) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29438587 | 0.81 | NPC1 (0.41) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL11616637 | 0.80 | NPC1 (0.43) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10788413 | 0.78 | NPC1 (0.53) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9269913 | 0.78 | NPC1 (0.42) | NPC1RAB9ALMNAKDM4EPOLB | |
| SCHEMBL11622645 | 0.76 | NPC1 (0.47) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29377081 | 0.75 | POLB (0.50) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3782539 | 0.75 | POLB (0.50) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16540651 | 0.75 | CYP3A4 (0.47) | NPC1RAB9ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563827-A1 | CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM | Momentive Performance Materials Inc. (US) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011139635-A1 | CHLORINE-RESISTANT CROSSLINKABLE POLYOLEFIN COMPOSITIONS AND ARTICLES MADE THEREFROM | MOMENTIVE PERFORMANCE MATERIALS INC. (US) | 2011-11-10 | — | — | WO | disclosed |