Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19426702 | 0.87 | IDO1 (0.49) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL21377414 | 0.86 | MEN1 (0.63) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL13734965 | 0.86 | MEN1 (0.63) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL28032815 | 0.86 | MEN1 (0.63) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL2349796 | 0.85 | IDO1 (0.46) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL12743181 | 0.84 | FADS1 (0.51) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL28360251 | 0.83 | RXFP1 (0.48) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL29910146 | 0.83 | RXFP1 (0.48) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL25810625 | 0.82 | PTGS1 (0.50) | IDO1MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL29029431 | 0.82 | HDAC3 (0.56) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |