Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | FADS1 | O60427 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ICMT | O60725 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830047 | 0.84 | PRMT5 (0.42) | PRMT5WDR77CSF1RSOS1ICMT | |
| SCHEMBL17308380 | 0.80 | SMN1; SMN2 (0.43) | PRMT5WDR77CSF1RGRIN2DGRIN3B | |
| SCHEMBL18466058 | 0.80 | PRMT5 (0.41) | PRMT5WDR77CSF1RRXFP1AKT1 | |
| SCHEMBL12963661 | 0.79 | PRMT5 (0.40) | PRMT5WDR77RXFP1FADS1MAPK1 | |
| SCHEMBL18672877 | 0.73 | BACE1 (0.39) | PRMT5WDR77RXFP1FADS1MAPK1 | |
| SCHEMBL17896338 | 0.73 | LMNA (0.62) | RXFP1FADS1LMNABRAF | |
| SCHEMBL8359919 | 0.71 | TDP1 (0.54) | RXFP1FADS1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL20045019 | 0.70 | CCR2 (0.35) | RXFP1FADS1MAPK1GRIN2DGRIN3B | |
| SCHEMBL20252397 | 0.70 | CCR2 (0.35) | RXFP1FADS1MAPK1GRIN2DGRIN3B | |
| SCHEMBL19633776 | 0.70 | SOS1 (0.46) | MAPK1SOS1KIF11CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |