Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.67 |
| ▸ | RAD52 | P43351 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | UBE2N | P61088 | 1/20 | 0.63 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.61 |
| ▸ | BCHE | P06276 | 4/20 | 0.59 |
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | APP | P05067 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3640101 | 0.87 | RAD52 (0.79) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2588903 | 0.85 | SOS1 (0.72) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2583209 | 0.85 | SOS1 (0.72) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL12176293 | 0.85 | SOS1 (0.72) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2583780 | 0.85 | PDE5A (0.67) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2583406 | 0.82 | PDE5A (0.64) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2592287 | 0.82 | SOS1 (0.71) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2588890 | 0.81 | SOS1 (0.70) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL2593693 | 0.81 | KMT2A (0.67) | PDE5ARAD52KDM4EMAPTKMT2A | |
| SCHEMBL12176129 | 0.81 | SLC2A1 (0.73) | PDE5ARAD52KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |