Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | PDE5A | O76074 | 2/20 | 0.67 |
| ▸ | RAD52 | P43351 | 1/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | UBE2N | P61088 | 1/20 | 0.63 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.63 |
| ▸ | BCHE | P06276 | 4/20 | 0.62 |
| ▸ | ACHE | P22303 | 4/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587460 | 0.89 | SOS1 (0.65) | SOS1MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL12175983 | 0.87 | RAD52 (0.76) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL3640101 | 0.87 | RAD52 (0.79) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL12175981 | 0.86 | SLC2A1 (0.76) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL2588903 | 0.85 | SOS1 (0.72) | SOS1MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL2590904 | 0.85 | PDE5A (0.67) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL2583780 | 0.85 | PDE5A (0.67) | MAPTNPSR1ALDH1A1LMNAKMT2A | |
| SCHEMBL2583209 | 0.85 | SOS1 (0.72) | SOS1MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL2588902 | 0.85 | SOS1 (0.66) | SOS1MAPTNPSR1ALDH1A1LMNA | |
| SCHEMBL2590870 | 0.85 | SLC2A1 (0.60) | SOS1MAPTNPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |