Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594247 | 0.78 | GPR119 (0.36) | GPR119SCDKCNH2 | |
| SCHEMBL15000391 | 0.76 | HTR2C (0.65) | HTR2CGRM7HRH1 | |
| SCHEMBL15393343 | 0.73 | GPR119 (0.46) | GPR119SCDKCNH2 | |
| SCHEMBL23384871 | 0.70 | HTR2C (0.48) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL30138444 | 0.70 | HTR2C (0.49) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2330910 | 0.69 | GPR119 (0.53) | GPR119SCD | |
| SCHEMBL26157259 | 0.69 | ALDH1A1 (0.40) | HTR2CKDM4ETSHR | |
| SCHEMBL29994691 | 0.68 | HRH1 (0.62) | HTR2CHRH1HTR1ASLC6A2SLC6A4 | |
| SCHEMBL2300978 | 0.68 | HRH1 (0.62) | HTR2CHRH1HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL71803 | 0.67 | HRH1 (0.61) | HTR2CHRH1HTR1ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566860-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140160-A1 | BICYCLIC HETEROARYL COMPOUNDS AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-11-10 | — | — | WO | disclosed |