Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | TNF | P01375 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591340 | 0.87 | NUDT1 (0.35) | ALOX5APFEN1MEN1HTTKMT2A | |
| SCHEMBL2591532 | 0.84 | MEN1 (0.36) | ALOX5APFEN1MEN1HTTKMT2A | |
| SCHEMBL2591433 | 0.82 | ALOX5AP (0.34) | ALOX5APFEN1TUBB1PDE4BPDE4D | |
| SCHEMBL2584271 | 0.81 | ALDH1A1 (0.41) | ALOX5APFEN1MEN1HTTKMT2A | |
| SCHEMBL2589057 | 0.81 | ALDH1A1 (0.33) | ALOX5APFEN1TUBB1PDE4BPDE4D | |
| SCHEMBL2582074 | 0.78 | TSHR (0.48) | MEN1HTTKMT2APDE4D | |
| SCHEMBL2584147 | 0.74 | CNR2 (0.34) | — | |
| SCHEMBL2589714 | 0.74 | ALDH1A1 (0.48) | MEN1KMT2A | |
| SCHEMBL31607167 | 0.73 | ALOX5AP (0.44) | ALOX5APFEN1HTTTUBB1PDE4B | |
| SCHEMBL22208768 | 0.73 | ALOX5AP (0.44) | ALOX5APFEN1HTTTUBB1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563770-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | Leo Pharma A/S (DK) | 2013-03-06 | — | — | EP | disclosed |
| WO-2011134468-A1 | BIARYL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2011-11-03 | — | — | WO | disclosed |