Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA7 | P43166 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1493352 | 0.89 | L3MBTL1 (0.51) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL4759383 | 0.88 | L3MBTL1 (0.50) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL25141302 | 0.88 | L3MBTL1 (0.50) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL12804233 | 0.88 | L3MBTL1 (0.50) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL3383513 | 0.87 | ALDH1A1 (0.49) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL2823114 | 0.86 | L3MBTL1 (0.49) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL20139154 | 0.86 | L3MBTL1 (0.49) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL7820903 | 0.85 | L3MBTL1 (0.46) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL10615235 | 0.85 | L3MBTL1 (0.46) | L3MBTL1CYP1A2LMNACYP3A4MAOA | |
| SCHEMBL2827826 | 0.85 | L3MBTL1 (0.48) | L3MBTL1CYP1A2LMNACYP3A4MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146809-A9 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | WO | disclosed |
| WO-2023146809-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-03 | — | — | WO | disclosed |