SCHEMBL25911782

SCHEMBL25911782

CC(C)C(=O)O[C@H]1[C@@H](O)[C@](C)(c2ccc3c(N)ncnn23)O[C@@H]1COC(=O)Cc1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ RIPK1 Q13546 5/20 0.33
▸ MGLL Q99685 2/20 0.31
▸ LMNA P02545 1/20 0.30
▸ KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24790490 0.94 RIPK1 (0.33) RIPK1LMNAKMT2A
SCHEMBL24917216 0.94 LMNA (0.33) RIPK1MGLLLMNAKMT2A
SCHEMBL24916817 0.93 RIPK1 (0.32) RIPK1
SCHEMBL24791010 0.92 CA12 (0.33) RIPK1
SCHEMBL24917051 0.92 LMNA (0.38) RIPK1MGLLLMNAKMT2A
SCHEMBL25911789 0.91 LMNA (0.32) RIPK1MGLLLMNAKMT2A
SCHEMBL24789413 0.91 CA12 (0.33) RIPK1LMNAKMT2A
SCHEMBL24790933 0.90 LMNA (0.32) RIPK1LMNAKMT2A
SCHEMBL24791782 0.90 RIPK1 (0.31) RIPK1
SCHEMBL25911901 0.89 RIPK1 (0.32) RIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS VenatoRx Pharmaceuticals, Inc. 2023-07-27 — — US disclosed
US-11638715-B2 Orally-bioavailable nucleoside analogs VenatoRx Pharmaceuticals, Inc. (US) 2023-05-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11638715-B2 Orally-bioavailable nucleoside analogs SLC29A2, SLC29A1, PNP RIPK1 2571/4885MGLL 1174/4885LMNA 1629/4885
US-20230233593-A1 ORALLY-BIOAVAILABLE NUCLEOSIDE ANALOGS SLC29A2, SLC29A1, PNP RIPK1 2571/4885MGLL 1174/4885LMNA 1629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback