Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 7/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25913433 | 0.82 | BRAF (0.46) | BRAF | |
| SCHEMBL25913399 | 0.80 | CSF1R (0.39) | MAOBMEN1ALDH1A1HTTKMT2A | |
| SCHEMBL25914740 | 0.78 | CSF1R (0.35) | MEN1ALDH1A1HTTKMT2ANOD2 | |
| SCHEMBL25911790 | 0.77 | CSF1R (0.53) | BRAFRAF1 | |
| SCHEMBL25914665 | 0.74 | CSF1R (0.39) | MAOBBRAFRAF1 | |
| SCHEMBL25913444 | 0.74 | ESR1 (0.48) | MAOAMAOBMEN1ALDH1A1KMT2A | |
| SCHEMBL25912706 | 0.73 | CSF1R (0.43) | MAOBBRAFRAF1 | |
| SCHEMBL25913040 | 0.72 | KDM4E (0.38) | ALDH1A1SCN7AKCNH2BRAF | |
| SCHEMBL25914331 | 0.69 | DYRK1A (0.35) | MEN1ALDH1A1KMT2ABRAFHDAC8 | |
| SCHEMBL25316908 | 0.69 | BRAF (0.32) | SCN7AKCNH2BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |