Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.58 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.58 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25322520 | 1.00 | PRMT5 (0.58) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL25322517 | 1.00 | PRMT5 (0.58) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL30668564 | 0.85 | PRMT5 (0.54) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL25320676 | 0.78 | PRMT5 (0.58) | PRMT5WDR77RIPK1 | |
| SCHEMBL25323862 | 0.78 | PRMT5 (0.58) | PRMT5WDR77RIPK1 | |
| SCHEMBL26984383 | 0.78 | PRMT5 (0.48) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL17788917 | 0.77 | RIPK1 (0.51) | PRMT5WDR77RIPK1GAA | |
| SCHEMBL25321623 | 0.76 | PRMT5 (0.48) | PRMT5WDR77RIPK1GAA | |
| SCHEMBL25321619 | 0.76 | PRMT5 (0.48) | PRMT5WDR77RIPK1GAA | |
| SCHEMBL25918195 | 0.76 | PRMT5 (0.48) | PRMT5WDR77RIPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |