Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.54 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 7/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20956526 | 0.88 | PRMT5 (0.44) | PRMT5WDR77RIPK1ACHEGAA | |
| SCHEMBL2597838 | 0.87 | PRMT5 (0.45) | PRMT5WDR77RIPK1GAAHTT | |
| SCHEMBL25322517 | 0.85 | PRMT5 (0.58) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL25322520 | 0.85 | PRMT5 (0.58) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL25918196 | 0.85 | PRMT5 (0.58) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL26984383 | 0.83 | PRMT5 (0.48) | PRMT5WDR77RIPK1ACHEPOLB | |
| SCHEMBL20956556 | 0.83 | PRMT5 (0.41) | PRMT5WDR77RIPK1ACHEGAA | |
| SCHEMBL17026995 | 0.83 | RIPK1 (0.67) | RIPK1POLBCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20449170 | 0.82 | RIPK1 (0.50) | RIPK1POLBHSD11B1BACE1 | |
| SCHEMBL20449214 | 0.82 | RIPK1 (0.50) | RIPK1POLBHSD11B1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551556-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | Vividion Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010784-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING WRN HELICASE INHIBITORS | VIVIDION THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |