Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2582202 | 0.83 | NPSR1 (1.00) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL18901345 | 0.71 | KMT2A (0.54) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL266148 | 0.70 | KMT2A (0.58) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL14039272 | 0.69 | KMT2A (0.57) | NPSR1HSD17B10KMT2AALDH1A1KDM4E | |
| SCHEMBL954146 | 0.69 | KMT2A (0.76) | NPSR1HSD17B10KMT2AALDH1A1MEN1 | |
| SCHEMBL15004608 | 0.69 | KMT2A (0.61) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL11357473 | 0.68 | KMT2A (0.56) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL9611707 | 0.68 | ALDH1A1 (0.56) | NPSR1HSD17B10HPGDKMT2AALDH1A1 | |
| SCHEMBL2590640 | 0.68 | NPSR1 (0.69) | NPSR1HPGDALDH1A1KDM4EGAA | |
| SCHEMBL792006 | 0.67 | KMT2A (0.59) | NPSR1HSD17B10HPGDKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137220-A1 | SMALL MOLECULE NEUROPEPTIDE S ANTAGONISTS FOR THE TREATMENT OF ADDICTIVE DISORDERS, MOOD, ANXIETY AND SLEEP DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-03 | — | — | WO | disclosed |
| WO-2011137220-A1 | SMALL MOLECULE NEUROPEPTIDE S ANTAGONISTS FOR THE TREATMENT OF ADDICTIVE DISORDERS, MOOD, ANXIETY AND SLEEP DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-11-03 | — | — | WO | disclosed |