Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25919688 | 0.85 | LIG1 (0.30) | LIG1 | |
| SCHEMBL25919211 | 0.78 | OPRM1 (0.41) | — | |
| SCHEMBL24638233 | 0.75 | ESR2 (0.54) | ALDH1A1 | |
| SCHEMBL18093828 | 0.73 | CYP2A6 (0.40) | CYP2A6TAAR1ALDH1A1 | |
| SCHEMBL19110540 | 0.71 | TAAR1 (0.43) | LIG1CYP2A6TAAR1ALDH1A1 | |
| SCHEMBL25919215 | 0.70 | CYP3A4 (0.31) | ALDH1A1 | |
| SCHEMBL25918786 | 0.69 | OPRM1 (0.44) | TAAR1 | |
| SCHEMBL16823730 | 0.68 | OPRL1 (0.50) | — | |
| SCHEMBL29119961 | 0.67 | TAAR1 (0.43) | LIG1CYP2A6TAAR1ALDH1A1 | |
| SCHEMBL3244627 | 0.67 | CYP2A6 (0.38) | LIG1CYP2A6TAAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |