Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 16/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594195 | 0.85 | HTR2C (0.35) | MAPK1 | |
| SCHEMBL3842494 | 0.85 | MAPK1 (0.32) | MAPK1 | |
| SCHEMBL2587023 | 0.85 | MAPT (0.36) | MAPK1 | |
| SCHEMBL18153814 | 0.85 | PBRM1 (0.34) | OPRD1KCNH2OPRK1CYP2D6CYP3A4 | |
| SCHEMBL3836335 | 0.84 | OPRD1 (0.36) | OPRD1KCNH2OPRK1CYP2D6MAPK1 | |
| SCHEMBL2589311 | 0.82 | OPRD1 (0.44) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL5291744 | 0.81 | CYP1A2 (0.36) | — | |
| SCHEMBL7845728 | 0.81 | OPRD1 (0.38) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL2594953 | 0.80 | GAA (0.43) | OPRD1KCNH2OPRK1CYP2D6OPRM1 | |
| SCHEMBL3457811 | 0.79 | OPRD1 (0.45) | OPRD1KCNH2OPRK1CYP2D6OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595989-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2011140425-A1 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-11-10 | — | — | WO | disclosed |
| EP-1675847-A4 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORP (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1871761-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | Adolor Corporation (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006105442-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2006-10-05 | — | — | WO | disclosed |
| EP-1675847-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | Adolor Corporation (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005033073-A2 | SPIROCYCLIC HETEROCYCLIC DERIVATIVES AND METHODS OF THEIR USE | ADOLOR CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |