Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591939 | 0.85 | OPRD1 (0.39) | MAPK1 | |
| SCHEMBL2587023 | 0.81 | MAPT (0.36) | MAPK1 | |
| SCHEMBL18153814 | 0.81 | PBRM1 (0.34) | MAPK1 | |
| SCHEMBL3836335 | 0.80 | OPRD1 (0.36) | MAPK1 | |
| SCHEMBL2594195 | 0.79 | HTR2C (0.35) | MAPK1 | |
| SCHEMBL5291744 | 0.78 | CYP1A2 (0.36) | — | |
| SCHEMBL1567927 | 0.73 | CYP11B2 (0.37) | — | |
| SCHEMBL4709980 | 0.71 | ACACA (0.36) | — | |
| SCHEMBL7845728 | 0.67 | OPRD1 (0.38) | — | |
| SCHEMBL2589311 | 0.66 | OPRD1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111406-A1 | SUBSTITUTED SPIROCHROMANONE DERIVATIVES AS ACC INHIBITORS | Merck & Co., Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008088688-A1 | SUBSTITUTED SPIROCHROMANONE DERIVATIVES AS ACC INHIBITORS | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008088689-A1 | SUBSTITUTED SPIROCHROMANONE DERIVATIVES AS ACC INHIBITORS | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |